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Chemical and biological studies of leaves and twigs of anogeissus rivularis and some hypoglycemic herbal formulations

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dc.contributor.author Hosen, Md. Anowar
dc.date.accessioned 2019-11-14T04:08:03Z
dc.date.available 2019-11-14T04:08:03Z
dc.date.issued 2019-04-25
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/1088
dc.description.abstract Hexane and Ethyl acetate extracts of leaves and twigs of Anogeissusrivularis and their sub-fractions were tested for anticancer activities on the six common human cancer cell lines; P-388, KB, HT-29, MCF-7, A549and two normal human kidney cell lines ASK and Hek293. Sub-fractions, 1F-3, 1F-5, Et-1F-2, Et-1F-3, and Et-1F-4 were found to possess significant anticancer activities (ED50 <4, 3.40, 4.50, 4.60 and 6.37 µg/mL respectively) on P-388 cell lines. The same extracts and their sub-fractions were also tested for anti-HIV-1 RT. The two extracts showed moderate activity but the two sub-fractions, 1F-5& Et-1F-7 were found to be very active (growth inhibition 97% & 92%, respectively). From the active extracts four new compounds namely, 2-(3՜,4՜-Dimethoxy-phenyl)-3-methyl-5-propenyl-2,3-dihydro-benzofuran (20), Dimer of 4,6-Dihydroxy-2-(4՜-hydroxy-benzyl)-benzofuran-3-one (21), 2-[(3՜,4՜-Dihydroxy-phenyl)-hydroxy-methyl]-4,6-dihydroxy-benzofuran-3-one (22), 2,5-Bis-[(4՜-hydroxy-phenyl)(4՜՜-hydroxy-phenyl)]-3,4-dimethyl-tetrahydro-furan-3-ol (23), together with thirteen known compounds namely, betulinic acid (3β-Hydroxy-19β-hydrogen-lup-20-(29)-en-28-oic acid)(3), 3β-Hydroxy-20(29)-en-lupan-30-al (6),29-Nor-20-oxolupeol (7), 3β,6β-Dihydroxylup-20(29)-ene(8),3,3՜,4՜-Tri-O-methylellagic acid (9),3,3՜-Di-O-methylellagic acid(12), (S)-naringenin(4՜,5,7-Trihydroxyflavanone) (13),p-Cumaric acid ((E)-3-(4՜-Hydroxyphenyl)-2-propenoic acid)(14),2,3-dihydro-p-cumaric acid(3-(4՜-Hydroxyphenyl)-propanoic acid)(15), protocatechuic acid (3,4-Dihydroxybenzoic acid)(16), Stigmast-5-en-3-O-β-glucoside(17),loliolide (6-Hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydro-4H-benzofuran-2-one) (18),vanillic acid (3-Methoxy 4-hydroxybenzoic acid) (19) were isolated by chromatographic techniques. The structure of this compounds were elucidated by spectroscopic methods using UV, FTIR, high resolution 1H &13C NMR and Mass spectrometry (HRMS-ESI-TOP) and Single Crystal X-ray Diffraction. en_US
dc.language.iso en en_US
dc.publisher University of Dhaka en_US
dc.title Chemical and biological studies of leaves and twigs of anogeissus rivularis and some hypoglycemic herbal formulations en_US
dc.type Thesis en_US

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